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排序方式: 共有10000条查询结果,搜索用时 732 毫秒
91.
92.
食物成瘾的研究进展及启示 总被引:2,自引:0,他引:2
食物成瘾是一种复杂的慢性疾病,导致人们在日常生活中对某种食物产生过度依赖与过度进食等相关行为特征,近年来已被认为是影响欧美发达国家肥胖症、暴食症、糖尿病等发病率持续升高的关键原因,引起学术界的极大关注,成为研究热点。本文主要介绍食物成瘾的概念、诊断标准,综述了食物成瘾的病理机制、影响因素和应对措施等方面的研究进展,并探讨食物成瘾对我国食品界的启示,为预防食物成瘾,保障公众健康提供有益借鉴。 相似文献
93.
94.
Deep Integration of Innovation and Entrepreneurship (InE) Education in Chinese University Classrooms
Recently, InE has been regarded as a popular education strategy in Chinese universities. However, problems have been exposed in the adoption of InE, for example, in InE courses and competitions. The purpose of this paper is to provide a possible solution to the problems, which is to organize effective InE courses by integrating InE with Inter-Course-level Problem-Based Learning (ICPBL). A detailed case is demonstrated by an ICPBL elective course design with deep integration of InE in the teaching, learning, and assessments. This paper contributes to a new curriculum design for promoting InE education in practically for Chinese universities. 相似文献
95.
Chen Tang Tiehu Li Yuhang Bai Junjie Gao Wenbo Yang Shasha Jiao Tingkai Zhao 《Ceramics International》2018,44(10):11812-11819
Recently, ceramic matrix composites reinforced by short carbon fibers (CFs) attracted increasing attentions. To further improve mechanical properties and oxidation resistances, CFs were subjected to oxidation and acidification followed by sol-gel dip-coating to deposit ZrO2 on their surfaces. ZrO2-Cf/SiC composites were fabricated by joint hot compression molding and sintering, compared to Cf/SiC and SiC prepared by the same method. Microstructural analyses indicated that ZrO2 coatings were successfully deposited on CF surfaces, formed strong bonding and interfaces between CF and the matrix. Meanwhile, CFs were found uniformly distributed in SiC matrix with random orientations. Flexural curves of ZrO2-Cf/SiC and Cf/SiC revealed the presence of “false plasticity” regions after sharp drops, which were quite different from brittle flexural behavior of SiC ceramic. Compression strength of the three samples showed step-up growth. ZrO2-Cf/SiC exhibited the highest value, indicating the introduction of CFs and ZrO2 coatings do have great influence on mechanical performances. After heat treatment, ZrO2-Cf/SiC exhibited better oxidation resistance than Cf/SiC, with weight loss ratios estimated to ??3.76% and ??6.43%, respectively. These improved properties indicated that ZrO2-Cf/SiC would be excellent alternatives to other existence materials under ultra-high temperature environments. 相似文献
96.
煤电平均供电煤耗作为评价能源系统效率的指标已在行业内广泛应用。但该项指标无法很好地反映一个国家、地区的用电结构与用电能耗水平。为此,参照行业内普遍采用的火电厂发电煤耗和供电煤耗指标,定义“综合用电煤耗”,即用户每用1 kW?h电“消耗”的标准煤量(单位:g/(kW?h))。在此基础上,提出“综合发电煤耗”与“综合供电煤耗”的概念,形成完整的指标评价体系。对近年典型省份指标值的研究表明,该指标体系能够很好地反映供给侧国家、省区或企业的发电结构与电能生产能耗水平。这一指标体系能够为正确理解和计算用电、输电与电能替代项目的化石能源消耗量及其排放量提供依据。 相似文献
97.
98.
Mingchang Lin Yufei Zhang Guosong Chen Ming Jiang 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(45):6065-6070
Glyco‐mimicking nanoparticles (glyco‐NPs) with Förster resonance energy transfer (FRET) donor and acceptor groups formed via dynamic covalent bond of benzoboroxole and sugar from two complementary polymers are prepared. The glyco‐NPs are proved to be quite stable under physiological conditions but sensitive to pH. So the glyco‐NPs can be internalized by dendritic cells with integrity and nontoxicity and then dissociate within the acidic organelles. This particle dissociation is directly observed and visualized in vitro, for the first time via the FRET measurements and fluorescent microscopy. This feature makes controlled release of drug or protein by glyco‐NPs possible, i.e., when model antigen Ovalbumin is loaded in the glyco‐NPs, the released Ovalbumin in dendritic cells stimulates T cells more efficiently than the free Ovalbumin itself as a result of the enhanced antigen processing and presentation. Thus, the results enlighten a bright future of the glyco‐NPs in immunotherapy. 相似文献
99.
周林 《计算机工程与应用》2019,55(8):264-270
针对交通拥挤环境下日益增长的城市配送需求,通过分析时序依赖对成本和碳排放的影响,引入车辆在节点等待和离散调度策略,研究基于时序依赖的低碳城市配送车辆路径与离散调度问题。为求解该问题,设计基于遗传算法与局部搜索相结合的混合进化搜索算法对模型求解,用积极的局部搜索机制替代随机的变异操作,并通过可行解构造算法、变概率交叉和多种局部搜索策略来提高算法求解质量和求解效率。通过对比仿真实验对算法和模型的有效性进行了验证。 相似文献
100.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献